diff --git a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.cc b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.cc
index 4ea1d75..fd6c9f3 100644
--- a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.cc
+++ b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.cc
@@ -17,6 +17,8 @@
 #include "chrome/browser/android/resource_mapper.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_delegate_android_impl.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_view.h"
+#include "chrome/browser/ui/android/tab_model/tab_model.h"
+#include "chrome/browser/ui/android/tab_model/tab_model_list.h"
 #include "chrome/browser/ui/autofill/autofill_suggestion_controller_utils.h"
 #include "chrome/browser/ui/autofill/payments/android_bnpl_ui_delegate.h"
 #include "components/autofill/content/browser/content_autofill_client.h"
@@ -31,6 +33,7 @@
 #include "components/autofill/core/browser/payments/payments_util.h"
 #include "components/autofill/core/browser/suggestions/suggestion.h"
 #include "content/public/browser/navigation_handle.h"
+#include "content/public/browser/render_widget_host_view.h"
 #include "content/public/browser/web_contents.h"
 #include "ui/android/window_android.h"
 
@@ -97,12 +100,22 @@
     return false;
   }
 
+  // The WebContents may have lost the focus because, for example, a new tab has
+  // just been opened.
+  // Beware that this check only works as intended before TTF is shown because
+  // the bottom sheet steals the focus from the RenderWidgetHostView.
+  if (auto* rwhv = web_contents()->GetRenderWidgetHostView();
+      !rwhv || !rwhv->HasFocus()) {
+    return false;
+  }
+
   if (IsPointerLocked(web_contents())) {
     return false;
   }
 
   // The bottom sheet steals the focus from the WebContents, so we cannot rely
-  // on AutofillPopupHideHelper's focus handling.
+  // on AutofillPopupHideHelper's focus handling. Instead, we check if
+  // `IsActiveWebContents()` in the event handlers below.
   AutofillPopupHideHelper::HidingParams params = {
       .hide_on_web_contents_lost_focus = false};
 
@@ -121,6 +134,11 @@
   return true;
 }
 
+bool TouchToFillPaymentMethodControllerImpl::IsActiveWebContents() {
+  TabModel* tab_model = TabModelList::GetTabModelForWebContents(web_contents());
+  return tab_model && tab_model->GetActiveWebContents() == web_contents();
+}
+
 bool TouchToFillPaymentMethodControllerImpl::ShowPaymentMethods(
     std::unique_ptr<TouchToFillPaymentMethodView> view,
     base::WeakPtr<TouchToFillDelegate> delegate,
@@ -395,55 +413,69 @@
     JNIEnv* env,
     const std::string& unique_id,
     bool is_virtual) {
-  if (delegate_) {
-    delegate_->CreditCardSuggestionSelected(unique_id, is_virtual);
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->CreditCardSuggestionSelected(unique_id, is_virtual);
 }
 
 void TouchToFillPaymentMethodControllerImpl::BnplSuggestionSelected(
     JNIEnv* env,
     std::optional<int64_t> extracted_amount) {
-  if (delegate_) {
-    delegate_->BnplSuggestionSelected(extracted_amount);
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->BnplSuggestionSelected(extracted_amount);
 }
 
 void TouchToFillPaymentMethodControllerImpl::LocalIbanSuggestionSelected(
     JNIEnv* env,
     const std::string& guid) {
-  if (delegate_) {
-    delegate_->IbanSuggestionSelected(Iban::Guid(guid));
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->IbanSuggestionSelected(Iban::Guid(guid));
 }
 
 void TouchToFillPaymentMethodControllerImpl::ServerIbanSuggestionSelected(
     JNIEnv* env,
     long instrument_id) {
-  if (delegate_) {
-    delegate_->IbanSuggestionSelected(Iban::InstrumentId(instrument_id));
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->IbanSuggestionSelected(Iban::InstrumentId(instrument_id));
 }
 
 void TouchToFillPaymentMethodControllerImpl::LoyaltyCardSuggestionSelected(
     JNIEnv* env,
     const LoyaltyCard& loyalty_card) {
-  if (delegate_) {
-    delegate_->LoyaltyCardSuggestionSelected(loyalty_card);
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->LoyaltyCardSuggestionSelected(loyalty_card);
 }
 
 void TouchToFillPaymentMethodControllerImpl::OnBnplIssuerSuggestionSelected(
     JNIEnv* env,
     const std::string& issuer_id) {
-  if (delegate_) {
-    delegate_->OnBnplIssuerSuggestionSelected(issuer_id);
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->OnBnplIssuerSuggestionSelected(issuer_id);
 }
 
 void TouchToFillPaymentMethodControllerImpl::OnBnplTosAccepted(JNIEnv* env) {
-  if (delegate_) {
-    delegate_->OnBnplTosAccepted();
+  if (!IsActiveWebContents() || !delegate_) {
+    Hide();
+    return;
   }
+  delegate_->OnBnplTosAccepted();
 }
 
 int TouchToFillPaymentMethodControllerImpl::GetJavaResourceId(
diff --git a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.h b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.h
index d13f469..3dd9892d 100644
--- a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.h
+++ b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl.h
@@ -129,6 +129,12 @@
 
  private:
   bool InitHideHelper(TouchToFillDelegate& delegate);
+
+  // The controller must ignore user actions if the associated WebContents is
+  // not active anymore. This is to handle race conditions between, for example,
+  // a new tab being opened and TTF being shown.
+  bool IsActiveWebContents();
+
   content::WebContents* web_contents();
 
   // Observes creation of ContentAutofillDrivers to inject a
diff --git a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
index 100fb31..00355f5 100644
--- a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
+++ b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
@@ -15,6 +15,8 @@
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_delegate_android_impl.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_view.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_view_controller.h"
+#include "chrome/browser/ui/android/tab_model/tab_model_list.h"
+#include "chrome/browser/ui/android/tab_model/tab_model_test_helper.h"
 #include "chrome/browser/ui/autofill/payments/android_bnpl_ui_delegate.h"
 #include "chrome/test/base/chrome_render_view_host_test_harness.h"
 #include "components/autofill/content/browser/test_autofill_client_injector.h"
@@ -147,6 +149,10 @@
               (std::optional<int64_t> extracted_amount),
               (override));
   MOCK_METHOD(void,
+              IbanSuggestionSelected,
+              ((std::variant<Iban::Guid, Iban::InstrumentId> backend_id)),
+              (override));
+  MOCK_METHOD(void,
               OnDismissed,
               (bool dismissed_by_user, bool should_reshow),
               (override));
@@ -191,6 +197,12 @@
 
   void SetUp() override {
     ChromeRenderViewHostTestHarness::SetUp();
+
+    tab_model_.emplace(profile());
+    TabModelList::AddTabModel(&*tab_model_);
+    tab_model_->SetWebContentsList({web_contents()});
+    tab_model_->SetIsActiveModel(true);
+
     NavigateAndCommit(GURL("about:blank"));
     FocusWebContentsOnMainFrame();
     ASSERT_TRUE(web_contents()->GetFocusedFrame());
@@ -200,6 +212,14 @@
     mock_view_ = std::make_unique<MockTouchToFillPaymentMethodViewImpl>();
   }
 
+  void AddSecondWebContents() {
+    CHECK(!second_web_contents_);
+    second_web_contents_ = content::WebContents::Create(
+        content::WebContents::CreateParams(profile()));
+    tab_model_->SetWebContentsList(
+        {second_web_contents_.get(), web_contents()});
+  }
+
   void SetUpIbanFormField() {
     some_form_data_ = autofill::test::CreateTestIbanFormData();
     some_form_ = some_form_data_.global_id();
@@ -214,6 +234,8 @@
 
   void TearDown() override {
     mock_view_.reset();
+    second_web_contents_.reset();
+    TabModelList::RemoveTabModel(&*tab_model_);
     ChromeRenderViewHostTestHarness::TearDown();
   }
 
@@ -301,6 +323,10 @@
       autofill_client_injector_;
   TestAutofillManagerInjector<TestBrowserAutofillManager>
       autofill_manager_injector_;
+
+  std::optional<TestTabModel> tab_model_;
+  std::unique_ptr<content::WebContents> second_web_contents_;
+
   FormData some_form_data_ =
       autofill::test::CreateTestCreditCardFormData(/*is_https=*/true,
                                                    /*use_month_type=*/false);
@@ -608,6 +634,30 @@
                                                      extracted_amount);
 }
 
+// Tests that accepting a (credit card) suggestion on TTF from an inactive tab
+// is a no-op.
+TEST_F(TouchToFillPaymentMethodControllerImplTest,
+       CreditCardSuggestionSelected_AbortsIfInactiveWebContents) {
+  MockTouchToFillPaymentMethodViewImpl* raw_mock_view = mock_view_.get();
+
+  OnBeforeAskForValuesToFill();
+  payment_method_controller().ShowPaymentMethods(
+      std::move(mock_view_), ttf_delegate().GetWeakPointer(), suggestions_);
+  OnAfterAskForValuesToFill();
+
+  AddSecondWebContents();
+
+  // Expect that Hide() is called on the view, and the delegate is NOT called.
+  EXPECT_CALL(*raw_mock_view, Hide());
+  EXPECT_CALL(ttf_delegate(), CreditCardSuggestionSelected).Times(0);
+
+  payment_method_controller().CreditCardSuggestionSelected(
+      /*env=*/nullptr, "some_guid", /*is_virtual=*/false);
+
+  testing::Mock::VerifyAndClearExpectations(raw_mock_view);
+  testing::Mock::VerifyAndClearExpectations(&ttf_delegate());
+}
+
 TEST_F(TouchToFillPaymentMethodControllerImplTest, ShowErrorScreenOnNewView) {
   const std::u16string title = u"Error Title";
   const std::u16string description = u"Error Description";
diff --git a/chrome/browser/touch_to_fill/autofill/android/BUILD.gn b/chrome/browser/touch_to_fill/autofill/android/BUILD.gn
index 38850beb..9252b1b 100644
--- a/chrome/browser/touch_to_fill/autofill/android/BUILD.gn
+++ b/chrome/browser/touch_to_fill/autofill/android/BUILD.gn
@@ -56,6 +56,7 @@
     "//base",
     "//chrome/android:chrome_jni_headers",
     "//chrome/browser/android:resource_mapper",
+    "//chrome/browser/ui/android/tab_model",
     "//chrome/browser/ui/autofill",
     "//chrome/browser/ui/autofill/payments",
     "//components/affiliations/core/browser:affiliations",
@@ -82,6 +83,7 @@
     ":public",
     "//base",
     "//base/test:test_support",
+    "//chrome/browser/ui/android/tab_model:test_support",
     "//chrome/browser/ui/autofill/payments",
     "//chrome/test:test_support",
     "//components/autofill/content/browser",

diff --git a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
index 100fb31..00355f5 100644
--- a/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
+++ b/chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_controller_impl_unittest.cc
@@ -15,6 +15,8 @@
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_delegate_android_impl.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_view.h"
 #include "chrome/browser/touch_to_fill/autofill/android/touch_to_fill_payment_method_view_controller.h"
+#include "chrome/browser/ui/android/tab_model/tab_model_list.h"
+#include "chrome/browser/ui/android/tab_model/tab_model_test_helper.h"
 #include "chrome/browser/ui/autofill/payments/android_bnpl_ui_delegate.h"
 #include "chrome/test/base/chrome_render_view_host_test_harness.h"
 #include "components/autofill/content/browser/test_autofill_client_injector.h"
@@ -147,6 +149,10 @@
               (std::optional<int64_t> extracted_amount),
               (override));
   MOCK_METHOD(void,
+              IbanSuggestionSelected,
+              ((std::variant<Iban::Guid, Iban::InstrumentId> backend_id)),
+              (override));
+  MOCK_METHOD(void,
               OnDismissed,
               (bool dismissed_by_user, bool should_reshow),
               (override));
@@ -191,6 +197,12 @@
 
   void SetUp() override {
     ChromeRenderViewHostTestHarness::SetUp();
+
+    tab_model_.emplace(profile());
+    TabModelList::AddTabModel(&*tab_model_);
+    tab_model_->SetWebContentsList({web_contents()});
+    tab_model_->SetIsActiveModel(true);
+
     NavigateAndCommit(GURL("about:blank"));
     FocusWebContentsOnMainFrame();
     ASSERT_TRUE(web_contents()->GetFocusedFrame());
@@ -200,6 +212,14 @@
     mock_view_ = std::make_unique<MockTouchToFillPaymentMethodViewImpl>();
   }
 
+  void AddSecondWebContents() {
+    CHECK(!second_web_contents_);
+    second_web_contents_ = content::WebContents::Create(
+        content::WebContents::CreateParams(profile()));
+    tab_model_->SetWebContentsList(
+        {second_web_contents_.get(), web_contents()});
+  }
+
   void SetUpIbanFormField() {
     some_form_data_ = autofill::test::CreateTestIbanFormData();
     some_form_ = some_form_data_.global_id();
@@ -214,6 +234,8 @@
 
   void TearDown() override {
     mock_view_.reset();
+    second_web_contents_.reset();
+    TabModelList::RemoveTabModel(&*tab_model_);
     ChromeRenderViewHostTestHarness::TearDown();
   }
 
@@ -301,6 +323,10 @@
       autofill_client_injector_;
   TestAutofillManagerInjector<TestBrowserAutofillManager>
       autofill_manager_injector_;
+
+  std::optional<TestTabModel> tab_model_;
+  std::unique_ptr<content::WebContents> second_web_contents_;
+
   FormData some_form_data_ =
       autofill::test::CreateTestCreditCardFormData(/*is_https=*/true,
                                                    /*use_month_type=*/false);
@@ -608,6 +634,30 @@
                                                      extracted_amount);
 }
 
+// Tests that accepting a (credit card) suggestion on TTF from an inactive tab
+// is a no-op.
+TEST_F(TouchToFillPaymentMethodControllerImplTest,
+       CreditCardSuggestionSelected_AbortsIfInactiveWebContents) {
+  MockTouchToFillPaymentMethodViewImpl* raw_mock_view = mock_view_.get();
+
+  OnBeforeAskForValuesToFill();
+  payment_method_controller().ShowPaymentMethods(
+      std::move(mock_view_), ttf_delegate().GetWeakPointer(), suggestions_);
+  OnAfterAskForValuesToFill();
+
+  AddSecondWebContents();
+
+  // Expect that Hide() is called on the view, and the delegate is NOT called.
+  EXPECT_CALL(*raw_mock_view, Hide());
+  EXPECT_CALL(ttf_delegate(), CreditCardSuggestionSelected).Times(0);
+
+  payment_method_controller().CreditCardSuggestionSelected(
+      /*env=*/nullptr, "some_guid", /*is_virtual=*/false);
+
+  testing::Mock::VerifyAndClearExpectations(raw_mock_view);
+  testing::Mock::VerifyAndClearExpectations(&ttf_delegate());
+}
+
 TEST_F(TouchToFillPaymentMethodControllerImplTest, ShowErrorScreenOnNewView) {
   const std::u16string title = u"Error Title";
   const std::u16string description = u"Error Description";