diff --git a/components/password_manager/core/browser/password_autofill_manager.cc b/components/password_manager/core/browser/password_autofill_manager.cc
index c0a87381c3786..80b7690cb85aa 100644
--- a/components/password_manager/core/browser/password_autofill_manager.cc
+++ b/components/password_manager/core/browser/password_autofill_manager.cc
@@ -289,6 +289,10 @@ void PasswordAutofillManager::DidAcceptSuggestion(
     const Suggestion& suggestion,
     const SuggestionMetadata& metadata) {
   using metrics_util::PasswordDropdownSelectedOption;
+  // On macOS, OnPasswordCredentialSuggestionAccepted() may synchronously spin
+  // a nested run loop (AuthorizationCopyRights) during which `this` can be
+  // destroyed. Guard the trailing member accesses below the switch.
+  auto weak_this = weak_ptr_factory_.GetWeakPtr();
   switch (suggestion.type) {
     case autofill::SuggestionType::kGeneratePasswordEntry:
       password_client_->GeneratePassword(PasswordGenerationType::kAutomatic);
@@ -430,6 +434,9 @@ void PasswordAutofillManager::DidAcceptSuggestion(
     }
   }
 
+  if (!weak_this) {
+    return;
+  }
   bool enter_loading_state =
       password_client_
           ->GetWebAuthnCredentialsDelegateForDriver(password_manager_driver_)