diff --git a/chrome/renderer/actor/click_dispatcher.cc b/chrome/renderer/actor/click_dispatcher.cc
index c0637b7f31f5d..dca24f3215636 100644
--- a/chrome/renderer/actor/click_dispatcher.cc
+++ b/chrome/renderer/actor/click_dispatcher.cc
@@ -54,8 +54,14 @@ ClickDispatcher::ClickDispatcher(
     mouse_move.SetPositionInWidget(target.widget_point);
 
     // Mouse move is considered optional, so we don't check this result.
+    // HandleInputEvent runs page script synchronously, which may detach this
+    // frame and destroy `this`. Guard with a weak self pointer.
+    auto weak_self = weak_ptr_factory_.GetWeakPtr();
     widget->HandleInputEvent(
         blink::WebCoalescedInputEvent(mouse_move, ui::LatencyInfo()));
+    if (!weak_self) {
+      return;
+    }
 
     base::TimeDelta delay = features::kGlicActorMoveBeforeClickDelay.Get();
     base::SequencedTaskRunner::GetCurrentDefault()->PostDelayedTask(
@@ -102,8 +108,15 @@ void ClickDispatcher::DoMouseDown(WebMouseEvent::Button button,
   //   mouse_event_.SetPositionInScreen(point.x() + offset.x(),
   //                                    point.y() + offset.y());
 
+  // HandleInputEvent runs page script synchronously (the page's `mousedown`
+  // listener), which may detach this local-root frame and destroy `this`.
+  // Guard with a weak self pointer.
+  auto weak_self = weak_ptr_factory_.GetWeakPtr();
   blink::WebInputEventResult result = widget->HandleInputEvent(
       blink::WebCoalescedInputEvent(mouse_down, ui::LatencyInfo()));
+  if (!weak_self) {
+    return;
+  }
 
   if (result == blink::WebInputEventResult::kHandledSuppressed) {
     Finish(MakeResult(mojom::ActionResultCode::kClickSuppressed,
@@ -124,7 +137,12 @@ void ClickDispatcher::DoMouseDown(WebMouseEvent::Button button,
 }
 
 void ClickDispatcher::DoMouseUp() {
+  // DoMouseUpImpl runs page script synchronously, which may destroy `this`.
+  auto weak_self = weak_ptr_factory_.GetWeakPtr();
   DoMouseUpImpl();
+  if (!weak_self) {
+    return;
+  }
   Finish(MakeOkResult());
 }
 
@@ -139,9 +157,15 @@ void ClickDispatcher::DoMouseUpImpl() {
   }
 
   mouse_up_event_->SetTimeStamp(ui::EventTimeForNow());
+  // HandleInputEvent runs page script synchronously, which may detach this
+  // frame and destroy `this`. Guard with a weak self pointer.
+  auto weak_self = weak_ptr_factory_.GetWeakPtr();
   blink::WebInputEventResult result =
       widget->HandleInputEvent(blink::WebCoalescedInputEvent(
           std::move(*mouse_up_event_), ui::LatencyInfo()));
+  if (!weak_self) {
+    return;
+  }
   mouse_up_event_.reset();
   if (result == blink::WebInputEventResult::kHandledSuppressed) {
     Finish(MakeResult(mojom::ActionResultCode::kClickSuppressed,