diff --git a/chrome/browser/printing/print_view_manager.cc b/chrome/browser/printing/print_view_manager.cc
index 03fe97357b5c8..3673a6c4d6caf 100644
--- a/chrome/browser/printing/print_view_manager.cc
+++ b/chrome/browser/printing/print_view_manager.cc
@@ -420,7 +420,14 @@ void PrintViewManager::OnScriptedPrintPreviewCallback(
   // Running a dialog causes an exit to webpage-initiated fullscreen.
   // https://crbug.com/41322524
   if (web_contents()->IsFullscreen()) {
+    // ExitFullscreen() may spin the message loop and synchronously destroy the
+    // WebContents (and therefore `this`, which is WebContentsUserData). See
+    // crbug.com/1506535, crbug.com/498752242.
+    auto weak_this = weak_factory_.GetWeakPtr();
     web_contents()->ExitFullscreen(true);
+    if (!weak_this) {
+      return;
+    }
   }
 
   auto* dialog_controller = PrintPreviewDialogController::GetInstance();