diff --git a/gpu/command_buffer/service/gles2_cmd_decoder_passthrough.cc b/gpu/command_buffer/service/gles2_cmd_decoder_passthrough.cc
index f9a8cd8a64bc8..788d2c94a89b2 100644
--- a/gpu/command_buffer/service/gles2_cmd_decoder_passthrough.cc
+++ b/gpu/command_buffer/service/gles2_cmd_decoder_passthrough.cc
@@ -1706,10 +1706,14 @@ void GLES2DecoderPassthroughImpl::MarkContextLost(
       resources_->MarkContextLost();
     }
 
-    // SECURITY: crbug.com/500187083. Unconditionally clear the debug callback
-    // if current context IsCurrent before it gets lost to prevent UAF.
+    // SECURITY: crbug.com/500187083. Unconditionally clear per-context
+    // callbacks that hold a raw `this` pointer if the context IsCurrent before
+    // it gets lost, to prevent UAF when Destroy(have_context=false) skips them.
     if (api()) {
       api()->glDebugMessageCallbackKHRFn(nullptr, nullptr);
+      if (feature_info_ && feature_info_->feature_flags().angle_blob_cache) {
+        api()->glBlobCacheCallbacksANGLEFn(nullptr, nullptr, nullptr);
+      }
     }
   }