diff --git a/chrome/browser/ui/views/autofill/popup/popup_view_views.cc b/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
index c4b19c7292bdf..260e20eeb2076 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
+++ b/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
@@ -323,7 +323,10 @@ bool PopupViewViews::Show(
   MaybeAnnounceCurrentTabAndFootnote();
   MaybeAnnouncePasswordRecoveryPopup();
   MaybeAnnounceLoadingState();
-  MaybeA11yFocusInformationalSuggestion();
+  if (!MaybeA11yFocusInformationalSuggestion()) {
+    // `this` was destroyed during the synchronous a11y event dispatch.
+    return false;
+  }
 
   return !CanActivate() || (GetWidget() && GetWidget()->IsActive());
 }
@@ -811,7 +814,10 @@ void PopupViewViews::OnSuggestionsChanged(bool prefer_prev_arrow_side) {
   MaybeAutoSelectSuggestion();
   MaybeAnnouncePasswordRecoveryPopup();
   MaybeAnnounceLoadingState();
-  MaybeA11yFocusInformationalSuggestion();
+  if (!MaybeA11yFocusInformationalSuggestion()) {
+    // `this` was destroyed during the synchronous a11y event dispatch.
+    return;
+  }
   ShowIPHFeaturePromos();
 }
 
@@ -1690,21 +1696,23 @@ bool PopupViewViews::SelectParentPopupContentCell() {
   return true;
 }
 
-void PopupViewViews::MaybeA11yFocusInformationalSuggestion() {
+bool PopupViewViews::MaybeA11yFocusInformationalSuggestion() {
   if (rows_.size() != 1) {
-    return;
+    return true;
   }
 
   if (auto* warning_view = std::get_if<PopupWarningView*>(&rows_[0]);
       warning_view && *warning_view) {
     PopupWarningView* view_ptr = *warning_view;
-    TrackAndRun(
+    return TrackAndRun(
         view_ptr, [this, view_ptr]() { NotifyAXSelection(*view_ptr); },
         [view_ptr]() {
           view_ptr->NotifyAccessibilityEventDeprecated(ax::mojom::Event::kFocus,
                                                        true);
         });
   }
+
+  return true;
 }
 
 base::WeakPtr<AutofillPopupView> PopupViewViews::GetWeakPtr() {
diff --git a/chrome/browser/ui/views/autofill/popup/popup_view_views.h b/chrome/browser/ui/views/autofill/popup/popup_view_views.h
index f984cc3acc95a..f4f81ea78df3b 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_view_views.h
+++ b/chrome/browser/ui/views/autofill/popup/popup_view_views.h
@@ -328,8 +328,10 @@ class PopupViewViews : public PopupBaseView,
   // suggestion with a special type in this case. This method makes sure
   // the suggestion's message is being announced to the user by focusing the row
   // view (which must be selectable). Currently, only `PopupWarningView` is
-  // supported.
-  void MaybeA11yFocusInformationalSuggestion();
+  // supported. Returns `false` if `this` was destroyed during the synchronous
+  // accessibility event dispatch (Windows ::NotifyWinEvent may pump a nested
+  // message loop).
+  [[nodiscard]] bool MaybeA11yFocusInformationalSuggestion();
 
   // Controller for this view.
   base::WeakPtr<AutofillPopupController> controller_ = nullptr;