diff --git a/components/autofill/core/browser/payments/virtual_card_enrollment_manager.cc b/components/autofill/core/browser/payments/virtual_card_enrollment_manager.cc
index 55fa906339d69..eb46396cd4355 100644
--- a/components/autofill/core/browser/payments/virtual_card_enrollment_manager.cc
+++ b/components/autofill/core/browser/payments/virtual_card_enrollment_manager.cc
@@ -339,8 +339,15 @@ void VirtualCardEnrollmentManager::OnDidGetUpdateVirtualCardEnrollmentResponse(
   // Relay the response to the server card editor page. This also destroys the
   // payments delegate if the editor was already closed.
   if (virtual_card_enrollment_update_response_callback_.has_value()) {
+    // The callback may synchronously destroy `this` (on Android the Java
+    // callback can call AutofillPaymentMethodsDelegate::Cleanup() which owns
+    // this object). Guard with a WeakPtr.
+    auto weak_this = weak_ptr_factory_.GetWeakPtr();
     std::move(virtual_card_enrollment_update_response_callback_.value())
         .Run(result);
+    if (!weak_this) {
+      return;
+    }
   }
 
   LogUpdateVirtualCardEnrollmentRequestResult(