diff --git a/ui/views/controls/menu/menu_controller.cc b/ui/views/controls/menu/menu_controller.cc
index 10649a65e5290..55e5877099c0d 100644
--- a/ui/views/controls/menu/menu_controller.cc
+++ b/ui/views/controls/menu/menu_controller.cc
@@ -907,13 +907,19 @@ bool MenuController::OnMousePressed(SubmenuView* source,
     View* view =
         forward_to_root->GetEventHandlerForPoint(event_for_root.location());
     Button* button = Button::AsButton(view);
+    // SetHotTrackedButton fires a11y events that can re-enter and delete
+    // `this` (see crbug.com/443019015 and SetSelection()), so capture a
+    // WeakPtr before calling it.
+    base::WeakPtr<MenuController> this_ref = AsWeakPtr();
     if (hot_button_ != button) {
       SetHotTrackedButton(button);
+      if (!this_ref) {
+        return true;
+      }
     }
 
     // Empty menu items are always handled by the menu controller.
     if (!IsViewClass<EmptyMenuMenuItem>(view)) {
-      base::WeakPtr<MenuController> this_ref = AsWeakPtr();
       bool processed = forward_to_root->ProcessMousePressed(event_for_root);
       // This object may be destroyed as a result of a mouse press event (some
       // item may close the menu).