diff --git a/ui/views/widget/widget.cc b/ui/views/widget/widget.cc
index 5c01e07d7d605..ee81ed3ded283 100644
--- a/ui/views/widget/widget.cc
+++ b/ui/views/widget/widget.cc
@@ -1615,10 +1615,18 @@ void Widget::SetCapture(View* view) {
   }
 
   if (!native_widget_->HasCapture()) {
+    // SetCapture() reaches the platform CaptureClient, which synchronously
+    // dispatches OnCaptureLost / kMouseCaptureChanged / touch-cancel events to
+    // other windows. Those handlers may close arbitrary widgets including
+    // |this|, so guard against use-after-free.
+    WidgetDeletionObserver widget_deletion_observer(this);
     native_widget_->SetCapture();
+    if (!widget_deletion_observer.IsWidgetAlive()) {
+      return;
+    }
 
     // Early return if setting capture was unsuccessful.
-    if (!native_widget_->HasCapture()) {
+    if (!native_widget_ || !native_widget_->HasCapture()) {
       return;
     }
   }