diff --git a/ui/base/x/x11_drag_drop_client.cc b/ui/base/x/x11_drag_drop_client.cc
index f1c43001fec27..0209900d3b77d 100644
--- a/ui/base/x/x11_drag_drop_client.cc
+++ b/ui/base/x/x11_drag_drop_client.cc
@@ -234,8 +234,14 @@ std::vector<x11::Atom> XDragDropClient::GetOfferedDragOperations() const {
 
 void XDragDropClient::CompleteXdndPosition(x11::Window source_window,
                                            const gfx::Point& screen_point) {
+  // delegate_->UpdateDrag() may spin a nested RunLoop that destroys |this|
+  // (via CloseNow -> ~X11Window -> ~XDragDropClient).
+  auto alive = weak_factory_.GetWeakPtr();
   DragOperation drag_operation =
       PreferredDragOperation(delegate_->UpdateDrag(screen_point));
+  if (!alive) {
+    return;
+  }
 
   // Sends an XdndStatus message back to the source_window. l[2,3]
   // theoretically represent an area in the window where the current action is
@@ -428,7 +434,13 @@ void XDragDropClient::OnXdndStatus(const x11::ClientMessageEvent& event) {
 
 void XDragDropClient::OnXdndLeave(const x11::ClientMessageEvent& event) {
   DVLOG(1) << "OnXdndLeave";
+  // delegate_->OnBeforeDragLeave() may spin a nested RunLoop that destroys
+  // |this| (via CloseNow -> ~X11Window -> ~XDragDropClient).
+  auto alive = weak_factory_.GetWeakPtr();
   delegate_->OnBeforeDragLeave();
+  if (!alive) {
+    return;
+  }
   ResetDragContext();
 }
 
@@ -437,7 +449,13 @@ void XDragDropClient::OnXdndDrop(const x11::ClientMessageEvent& event) {
 
   auto source_window = static_cast<x11::Window>(event.data.data32[0]);
 
+  // delegate_->PerformDrop() may spin a nested RunLoop that destroys |this|
+  // (via CloseNow -> ~X11Window -> ~XDragDropClient).
+  auto alive = weak_factory_.GetWeakPtr();
   DragOperation drag_operation = delegate_->PerformDrop();
+  if (!alive) {
+    return;
+  }
 
   auto xev = PrepareXdndClientMessage(kXdndFinished, source_window);
   xev.data.data32[1] = (drag_operation != DragOperation::kNone) ? 1 : 0;
diff --git a/ui/base/x/x11_drag_drop_client.h b/ui/base/x/x11_drag_drop_client.h
index 88360078bbcdb..f5f7717c64111 100644
--- a/ui/base/x/x11_drag_drop_client.h
+++ b/ui/base/x/x11_drag_drop_client.h
@@ -9,6 +9,7 @@
 
 #include "base/component_export.h"
 #include "base/memory/raw_ptr.h"
+#include "base/memory/weak_ptr.h"
 #include "base/timer/timer.h"
 #include "ui/base/dragdrop/mojom/drag_drop_types.mojom-shared.h"
 #include "ui/base/x/selection_utils.h"
@@ -251,6 +252,8 @@ class COMPONENT_EXPORT(UI_BASE_X) XDragDropClient {
   // only if we have previously received a status message from
   // |source_current_window_|.
   bool status_received_since_enter_ = false;
+
+  base::WeakPtrFactory<XDragDropClient> weak_factory_{this};
 };
 
 }  // namespace ui